Cyclist Alejandro Díaz de la Peña, from Almendralejo, and Pedro Romero, from Plasencia, won the Aquarex - Val Serena race for the second year running.
The Madrid cyclists Jesús del Nero and Juan Carlos Fernández won the Medellín time trial.
The Extremadura Ecopilas racers achieved overall victory after the 71 kilometre stage of the race.